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BCI hydrochloride
CAS No. 95130-23-7
BCI hydrochloride( —— )
Catalog No. M32799 CAS No. 95130-23-7
BCI hydrochloride ((E)-BCI hydrochloride) is a selective dual-specificity phosphatase 6 (DUSP6) inhibitor that inhibits RANKL-mediated osteoclastogenesis and attenuates oophorectomy-induced bone loss.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBCI hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBCI hydrochloride ((E)-BCI hydrochloride) is a selective dual-specificity phosphatase 6 (DUSP6) inhibitor that inhibits RANKL-mediated osteoclastogenesis and attenuates oophorectomy-induced bone loss.
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DescriptionBCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research.
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In VitroWestern Blot Analysis Cell Line:RAW264.7 macrophage cells Concentration:100 ng/mL Incubation Time:24 hours Result:Showed DUSP6 protein down regulation.RT-PCR Cell Line:RAW264.7 macrophage cells Concentration:0-1 nM Incubation Time:24 hours Result:Inhibited the expression of IL-1β and IL-6 mRNA in LPS-activated macrophages.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorPhosphatase
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Research Area——
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Indication——
Chemical Information
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CAS Number95130-23-7
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Formula Weight353.89
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Molecular FormulaC22H24ClNO
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 15.62 mg/mL (44.14 mM; Ultrasonic )
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SMILESCl.O=C1C=2C=CC=CC2C(NC3CCCCC3)C1=CC=4C=CC=CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.?
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