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Raphin1
CAS No. 2022961-17-5
Raphin1( —— )
Catalog No. M21085 CAS No. 2022961-17-5
Raphin1 is an orally bioavailable selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | Get Quote |
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| 5MG | 64 | Get Quote |
|
| 10MG | 102 | Get Quote |
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| 25MG | 183 | Get Quote |
|
| 50MG | 275 | Get Quote |
|
| 100MG | 411 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRaphin1
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NoteResearch use only, not for human use.
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Brief DescriptionRaphin1 is an orally bioavailable selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
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DescriptionRaphin1 is an orally bioavailable selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
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In VitroRaphin1 causes a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.
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In VivoRaphin1 improves weight of HD82Q mice treated from 4 to ～10 weeks of age with 2 mg/kg of Raphin1 once a day by oral gavage. Raphin1 also decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in the cortex of HD82Q mice.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorPhosphatase
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Research Area——
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Indication——
Chemical Information
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CAS Number2022961-17-5
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Formula Weight231.08
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Molecular FormulaC8H8Cl2N4
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL?(540.94 mM ;?
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SMILESN=C(N)N/N=C/c1cccc(Cl)c1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Krzyzosiak A Sigurdardottir A Luh Let al.Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.Cell. 2018 Aug 23 ;174(5):1216-1228.e19.?
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