p-Ethynylphenylalanine( —— )

Catalog No. M32752 CAS No. 278605-15-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

p-Ethynylphenylalanine
Note

Research use only, not for human use.
Brief Description

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a selective, effective, and reversible tryptophan hydroxylase (TPH) inhibitor, exhibits competitive inhibition with a Ki of 32.6 μM.
Description

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
In Vitro

——
In Vivo

Animal Model:Male Sprague-Dawley rats (200 g) Dosage:30 mg/kg Administration:Intraperitoneal injection Result:Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
Synonyms

——
Pathway

Immunology/Inflammation
Target

Hydroxylase
Recptor

Hydroxylase
Research Area

——
Indication

——

CAS Number

278605-15-5
Formula Weight

189.21
Molecular Formula

C11H11NO2
Purity

>98% (HPLC)
Solubility

In Vitro:?1M HCl : 240 mg/mL (1268.43 mM; Ultrasonic; (HCL ，pH≈1) 1M NaOH : 240 mg/mL (1268.43 mM; ultrasonic and adjust pH to 11 with NaOH) DMSO : 2.22 mg/mL (11.73 mM; Ultrasonic )
SMILES

N[C@@H](Cc1ccc(cc1)C#C)C(O)=O
Chemical Name

——

1. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.?

Calculator

molnova catalog