ACT-678689( Compound Example 1.53.4 )

Catalog No. M23798 CAS No. 1783256-96-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ACT-678689
Note

Research use only, not for human use.
Brief Description

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.
Description

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.
In Vitro

TPH comprises two isoforms: TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS), while TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets.
In Vivo

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Synonyms

Compound Example 1.53.4
Pathway

Immunology/Inflammation
Target

Hydroxylase
Recptor

Tryptophan hydroxylase
Research Area

——
Indication

——

CAS Number

1783256-96-1
Formula Weight

565.04
Molecular Formula

C23H22ClFN6O4S2
Purity

>98% (HPLC)
Solubility

DMSO:120 mg/mL (212.37 mM; Need ultrasonic)
SMILES

Cc(s1)nn2c1nc(CC1)c2[C@H](c(ccc(C)c2)c2F)N1C(COc1ccc(NS(C)(=O)=O)nc1Cl)=O
Chemical Name

——

1.Daniel Bur, et al. Tricyclic piperidine compounds. WO2015075023A1.

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