p-Ethynylphenylalanine hydrochloride

Research use only, not for human use.

p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH.

p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the biosynthesis of serotonin may contribute to the characterization of the role of serotonin in behavioral and physiological activities.(In Vitro):p-Ethynylphenylalanine hydrochloride was demonstrated to inhibit competitively and reversibly TPH in vitro (Ki = 32.6 +/- 6.2 microM vs. tryptophan). (In Vivo):Administration of p-Ethynylphenylalanine hydrochloride (30 mg/kg) to rats produced a 95 +/- 5% decrease in TPH activity in brain homogenates and a concomitant decrease in serotonin and 5-hydroxyindole-3-acetic acid levels (85%) at 24 h after injection.

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Animal Model:Male Sprague-Dawley rats (200 g)Dosage:30 mg/kg Administration:Intraperitoneal injection Result:Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) | 4-Ethynyl-L-phenylalanine HCL

Immunology/Inflammation

Hydroxylase

Endogenous Metabolite

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188640-63-3

225.67

C11H12ClNO2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (221.56 mM)

N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years