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Sarafotoxin S6c

CAS No. 121695-87-2

Sarafotoxin S6c( —— )

Catalog No. M30800 CAS No. 121695-87-2

Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Sarafotoxin S6c
  • Note
    Research use only, not for human use.
  • Brief Description
    Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).
  • Description
    Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).
  • In Vitro
    ——
  • In Vivo
    Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels. Animal Model:Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeksDosage:1 pM-1 mMAdministration:Result:Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident.Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Endothelin Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    121695-87-2
  • Formula Weight
    2516
  • Molecular Formula
    C103H147N27O37S5
  • Purity
    >98% (HPLC)
  • Solubility
    water:1 mg/mL
  • SMILES
    [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Matsuo et al (1997) Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 280 905 PMID:
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