CTTHWGFTLC, CYCLIC
CAS No. 244082-19-7
CTTHWGFTLC, CYCLIC( —— )
Catalog No. M30200 CAS No. 244082-19-7
This cyclic CTT Gelatinase Inhibitor peptide is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of these enzymes can prevent tumor progression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCTTHWGFTLC, CYCLIC
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NoteResearch use only, not for human use.
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Brief DescriptionThis cyclic CTT Gelatinase Inhibitor peptide is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of these enzymes can prevent tumor progression.
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DescriptionThis cyclic CTT Gelatinase Inhibitor peptide is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of these enzymes can prevent tumor progression.
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In VitroCTTHWGFTLC, CYCLIC inhibits endothelial and tumor cell migration in vitro.
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In VivoCTTHWGFTLC, CYCLIC inhibits tumor progression in vivo, in mouse models.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number244082-19-7
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Formula Weight1166.33
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Molecular FormulaC52H71N13O14S2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameSequence:{Cys}{Thr}{Thr}{His}{Trp}{Gly}{Phe}{Thr}{Leu}{Cys} (Disulfide Bridge: Cys1-Cys10)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61(10):3978-85.
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