Atrasentan hydrochloride

CAS No. 195733-43-8

Atrasentan hydrochloride( ABT-627 hydrochloride | (+)-A 127722 hydrochloride | A-147627 hydrochloride )

Catalog No. M29618 CAS No. 195733-43-8

Atrasentan hydrochloride is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 112 In Stock
5MG 93 In Stock
10MG 132 In Stock
25MG 264 In Stock
50MG 368 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Atrasentan hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Atrasentan hydrochloride is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).
  • Description
    Atrasentan hydrochloride is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).(In Vitro):Atrasentan hydrochloride (0-50 μM) significantly inhibits LNCaP and C4-2b prostate cancer cell growth. ABT-627 in combination with Taxotere elicits a significantly greater loss of viable prostate cancer cells relative to either agent alone and shows a greater degree of down-regulation of the NF-κB DNA binding activity . Atrasentan hydrochloride profoundly induces several CYPs and drug transporters. It is a moderate P-gp inhibitor (IC50 = 15.1 μM in P388/dx cells) and a weak BCRP inhibitor (IC50 = 59.8 μM in MDCKII-BCRP cells) .(In Vivo):Atrasentan hydrochloride (10 mg/kg, i.p.) inhibited the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model . Atrasentan hydrochloride (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ABT-627 hydrochloride | (+)-A 127722 hydrochloride | A-147627 hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Endothelin Receptor
  • Recptor
    Endothelin Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    195733-43-8
  • Formula Weight
    547.09
  • Molecular Formula
    C29H39ClN2O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 28.57 mg/mL (52.22 mM)
  • SMILES
    Cl.CCCCN(CCCC)C(=O)CN1CC(C(C1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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