CVT-313( CVT-313 | CVT 313 | CVT313 )

Catalog No. M17417 CAS No. 199986-75-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CVT-313
Note

Research use only, not for human use.
Brief Description

CVT-313(NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.
Description

CVT-313 is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation. CVT-313 has an IC50 of 0.5 microM in vitro. Inhibition was competitive with respect to ATP (Ki = 95 nM), and selective CVT-313 had no effect on other, nonrelated ATP-dependent serine/threonine kinases. The growth of mouse, rat, and human cells in culture was also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 microM. CVT-313 is a promising candidate for evaluation in other disease models related to aberrant cell proliferation.
In Vitro

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In Vivo

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Synonyms

CVT-313 | CVT 313 | CVT313
Pathway

GPCR/G Protein
Target

Endothelin Receptor
Recptor

CDK1| CDK2| CDK4
Research Area

Cancer
Indication

——

CAS Number

199986-75-9
Formula Weight

400.47
Molecular Formula

C20H28N6O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL; 249.71 mM
SMILES

CC(C)n1cnc2c1nc(nc2NCc1ccc(cc1)OC)N(CCO)CCO
Chemical Name

2,2'-((9-isopropyl-6-((4-methoxybenzyl)amino)-9H-purin-2-yl)azanediyl)bis(ethan-1-ol)

1. Brooks EE, et al. J Biol Chem. 1997 Nov 14;272(46):29207-11.

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