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CVT-313
CAS No. 199986-75-9
CVT-313( CVT-313 | CVT 313 | CVT313 )
Catalog No. M17417 CAS No. 199986-75-9
CVT-313(NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 109 | In Stock |
|
| 25MG | 197 | In Stock |
|
| 50MG | 360 | In Stock |
|
| 100MG | 536 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCVT-313
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NoteResearch use only, not for human use.
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Brief DescriptionCVT-313(NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.
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DescriptionCVT-313 is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation. CVT-313 has an IC50 of 0.5 microM in vitro. Inhibition was competitive with respect to ATP (Ki = 95 nM), and selective CVT-313 had no effect on other, nonrelated ATP-dependent serine/threonine kinases. The growth of mouse, rat, and human cells in culture was also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 microM. CVT-313 is a promising candidate for evaluation in other disease models related to aberrant cell proliferation.
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In Vitro——
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In Vivo——
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SynonymsCVT-313 | CVT 313 | CVT313
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PathwayGPCR/G Protein
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TargetEndothelin Receptor
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RecptorCDK1| CDK2| CDK4
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number199986-75-9
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Formula Weight400.47
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Molecular FormulaC20H28N6O3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL; 249.71 mM
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SMILESCC(C)n1cnc2c1nc(nc2NCc1ccc(cc1)OC)N(CCO)CCO
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Chemical Name2,2'-((9-isopropyl-6-((4-methoxybenzyl)amino)-9H-purin-2-yl)azanediyl)bis(ethan-1-ol)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brooks EE, et al. J Biol Chem. 1997 Nov 14;272(46):29207-11.
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