Effusanin A( —— )

Catalog No. M29298 CAS No. 30220-43-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Effusanin A
Note

Research use only, not for human use.
Brief Description

Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repairs proficient (RAD +) yeast strains. Effusanin A shows inhibitory effects on DU145 cells with IC50 value of 3.16 μM, and LoVo cells with IC50 value of 3.02 μM.
Description

Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repairs proficient (RAD +) yeast strains. Effusanin A shows inhibitory effects on DU145 cells with IC50 value of 3.16 μM, and LoVo cells with IC50 value of 3.02 μM.(In Vitro):A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy- ent-kauranoids. Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function. These compounds have exhibited DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.
In Vitro

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In Vivo

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Synonyms

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Pathway

MAPK/ERK Signaling
Target

Raf
Recptor

Raf
Research Area

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Indication

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CAS Number

30220-43-0
Formula Weight

348.43
Molecular Formula

C20H28O5
Purity

>98% (HPLC)
Solubility

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SMILES

C=C([C@H](CC1)C2)C([C@@]32[C@]4(O)[C@@H](O)[C@]5([H])C(C)(C)CC[C@H](O)[C@@]5(CO4)[C@@]31[H])=O
Chemical Name

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