Cart
sales@molnova.com
RRD-251
CAS No. 131916-62-6
RRD-251( RRD251 )
Catalog No. M11292 CAS No. 131916-62-6
RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameRRD-251
-
NoteResearch use only, not for human use.
-
Brief DescriptionRRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM).
-
DescriptionRRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding; inhibits Rb to recruit Raf-1 to proliferative promoters and inhibited E2F1-dependent transcriptional activity; inhibits anchorage-dependent and anchorage-independent growth of human cancer cells; significantly inhibits tumor growth in tumors with functional Rb in vivo.
-
In Vitro——
-
In Vivo——
-
SynonymsRRD251
-
PathwayMAPK/ERK Signaling
-
TargetRaf
-
RecptorRaf
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number131916-62-6
-
Formula Weight235.126
-
Molecular FormulaC8H8Cl2N2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1=CC(=C(C=C1Cl)Cl)CSC(=N)N
-
Chemical Name2,4-dichlorobenzyl carbamimidothioate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kinkade R, et al. Cancer Res. 2008 May 15;68(10):3810-8.
2. Singh S, et al. Mol Cancer Ther. 2010 Dec;9(12):3330-41.
3. Trevi?o JG, et al. Mol Cancer Ther. 2013 Dec;12(12):2722-34.
4. Wallace AS, et al. Oncotarget. 2016 Jul 19;7(29):46401-46418.
molnova catalog
related products
-
MRTX0902
MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.
-
EBI-907
EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM.
-
lavendustin C
Lavendustin C is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
