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Home - Products - MAPK/ERK Signaling - Raf - RRD-251

RRD-251

CAS No. 131916-62-6

RRD-251( RRD251 )

Catalog No. M11292 CAS No. 131916-62-6

RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RRD-251
  • Note
    Research use only, not for human use.
  • Brief Description
    RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM).
  • Description
    RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding; inhibits Rb to recruit Raf-1 to proliferative promoters and inhibited E2F1-dependent transcriptional activity; inhibits anchorage-dependent and anchorage-independent growth of human cancer cells; significantly inhibits tumor growth in tumors with functional Rb in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RRD251
  • Pathway
    MAPK/ERK Signaling
  • Target
    Raf
  • Recptor
    Raf
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    131916-62-6
  • Formula Weight
    235.126
  • Molecular Formula
    C8H8Cl2N2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC(=C(C=C1Cl)Cl)CSC(=N)N
  • Chemical Name
    2,4-dichlorobenzyl carbamimidothioate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kinkade R, et al. Cancer Res. 2008 May 15;68(10):3810-8. 2. Singh S, et al. Mol Cancer Ther. 2010 Dec;9(12):3330-41. 3. Trevi?o JG, et al. Mol Cancer Ther. 2013 Dec;12(12):2722-34. 4. Wallace AS, et al. Oncotarget. 2016 Jul 19;7(29):46401-46418.
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