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Glabrone

CAS No. 60008-02-8

Glabrone( —— )

Catalog No. M29153 CAS No. 60008-02-8

Glabrone shows antiviral activity against influenza virus.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Glabrone
  • Note
    Research use only, not for human use.
  • Brief Description
    Glabrone shows antiviral activity against influenza virus.
  • Description
    Glabrone shows antiviral activity against influenza virus.(In Vitro):On the basis of a shape-focused virtual screening, the roots of Glycyrrhiza glabra (licorice) were identified as plant species with an accumulation of constituents that show 3D similarities to known influenza NA inhibitors (NAIs). Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), Glabrone (5), hispaglabridin B (6), licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Influenza Virus
  • Recptor
    Influenza Virus
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    60008-02-8
  • Formula Weight
    336.343
  • Molecular Formula
    C20H16O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1(C)Oc2ccc(c(O)c2C=C1)-c1coc2cc(O)ccc2c1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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