Polyporenic acid C( —— )

Catalog No. M29062 CAS No. 465-18-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Polyporenic acid C
Note

Research use only, not for human use.
Brief Description

Polyporenic acid C shows inhibitory activity against human collagenase.
Description

Polyporenic acid C shows inhibitory activity against human collagenase.(In Vitro):Polyporenic acid C (PPAC) significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with PPAC was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, PPC-induced apoptosis was inhibited by caspase-8 and pan-caspase inhibitors but not by a caspase-9 inhibitor.
In Vitro

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In Vivo

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Synonyms

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Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

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Indication

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CAS Number

465-18-9
Formula Weight

482.705
Molecular Formula

C31H46O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 16.67 mg/mL (34.54 mM)
SMILES

[H][C@@]12CC=C3C(=CC[C@]4(C)[C@@H]([C@@H](CCC(=C)C(C)C)C(O)=O)[C@H](O)C[C@@]34C)[C@@]1(C)CCC(=O)C2(C)C
Chemical Name

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