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Cedirogant

CAS No. 2055496-11-0

Cedirogant( ABBV-157 )

Catalog No. M28818 CAS No. 2055496-11-0

Cedirogant is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 207 In Stock
5MG 170 In Stock
10MG 274 In Stock
25MG 497 In Stock
50MG 727 In Stock
100MG 1079 In Stock
200MG 1451 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Cedirogant
  • Note
    Research use only, not for human use.
  • Brief Description
    Cedirogant is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.
  • Description
    Cedirogant is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.
  • In Vitro
    The transcription factor retinoic acid-related orphan receptor gamma t (RORγt) has been identified as the master regulator of TH17 cell differentiation and IL-17/22 production and is therefore an attractive target for the treatment of inflammatory diseases. Cedirogant (ABBV-157) has the potential for chronic plaque psoriasis research.
  • In Vivo
    ——
  • Synonyms
    ABBV-157
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    ROR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2055496-11-0
  • Formula Weight
    547.78
  • Molecular Formula
    C24H20Cl3F3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (456.39 mM)
  • SMILES
    OC(CC(CC1)CCN1C(c(ccc(Cl)c1Cn(ccc2cc(C(F)(F)F)c3)c2c3Cl)c1Cl)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wu Y, et al. Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. J Biomol Screen. 2016 Jan;21(1):74-87.
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