Sovilnesib( AMG 650 )

Catalog No. M28250 CAS No. 2410796-79-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Sovilnesib
Note

Research use only, not for human use.
Brief Description

Sovilnesib is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer.
Description

Sovilnesib is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer.(In Vitro):Sovilnesib is a kinesin-like protein KIF18A inhibitor.
In Vitro

Cell Viability Assay Cell Line:Cancer cell lines Concentration:0-10 pM Incubation Time:96 and 144 hours Result:Inhibited tumor cell growth in a dose-dependent manner.
In Vivo

Animal Model:Female nude mice without thymus with OVCAR-3 xenografts Dosage:10, 30, and 100 mg/kg Administration:Oral administration; daily, for 45 days Result:Had antitumor efficacy in a dose-dependent manner.
Synonyms

AMG 650
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

Histamine relase
Research Area

——
Indication

——

CAS Number

2410796-79-9
Formula Weight

564.65
Molecular Formula

C26H34F2N6O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (177.10 mM)
SMILES

Cc1cc(NC(c(ccc(NS(CCO)(=O)=O)c2)c2N2CCC3(CC3)CC2)=O)nc(N(CC2)CCC2(F)F)n1
Chemical Name

——

1.Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94.

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