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Home - Products - Angiogenesis - CDK - CDK4/6-IN-6

CDK4/6-IN-6

CAS No. 2380321-51-5

CDK4/6-IN-6( —— )

Catalog No. M28244 CAS No. 2380321-51-5

CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CDK4/6-IN-6
  • Note
    Research use only, not for human use.
  • Brief Description
    CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
  • Description
    CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.(In Vitro):Using phosphorylated Rb S795 ELISA assay in JEKO-1 cells, CDK4/6-IN-6 has IC50s of 38.5 nM for CDK4/Cyclin D1 and 144.9 nM for CDK6/Cyclin D3, respectively .
  • In Vitro
    PF-07220060 (CDK4/6-IN-6; example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    NR2B-NMDA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2380321-51-5
  • Formula Weight
    463.93
  • Molecular Formula
    C22H27ClFN5O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (538.87 mM)
  • SMILES
    CC(C)n1c2cc(-c(nc(N[C@H](CCOC3)[C@@H]3O)nc3)c3Cl)cc(F)c2nc1C(C)(C)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Fischer G, et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.
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