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JNJ-7706621

CAS No. 443797-96-4

JNJ-7706621( JNJ7706621 | JNJ 7706621 )

Catalog No. M14517 CAS No. 443797-96-4

A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 86 In Stock
5MG 102 In Stock
10MG 158 In Stock
25MG 282 In Stock
50MG 445 In Stock
100MG 616 In Stock
200MG 861 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    JNJ-7706621
  • Note
    Research use only, not for human use.
  • Brief Description
    A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM).
  • Description
    A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM), and no activity for Plk1 or Wee1; arrests the cell cycle at the G2-M phase; shows significant antitumor activity in tumor xenograft model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JNJ7706621 | JNJ 7706621
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    AuroraA|AuroraB|CDK1/CyclinB|CDK2/CyclinA|CDK2/CyclinE
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    443797-96-4
  • Formula Weight
    394.356
  • Molecular Formula
    C15H12F2N6O3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=S(C1=CC=C(NC2=NN(C(C3=C(F)C=CC=C3F)=O)C(N)=N2)C=C1)(N)=O
  • Chemical Name
    Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Emanuel S, et al. Cancer Res. 2005 Oct 1;65(19):9038-46. 2. Huang S, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. 3. Seamon JA, et al. Mol Cancer Ther. 2006 Oct;5(10):2459-67.
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