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CGP-74514A hydrochloride
CAS No. 481724-82-7
CGP-74514A hydrochloride( CGP74514A )
Catalog No. M14612 CAS No. 481724-82-7
CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCGP-74514A hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.
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DescriptionCGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM; induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells; increases p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2).
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In Vitro——
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In Vivo——
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SynonymsCGP74514A
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number481724-82-7
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Formula Weight422.35
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Molecular FormulaC19H24ClN7 · HCl
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Purity>98% (HPLC)
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Solubility——
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SMILESCCN1C=NC2=C(NC3=CC=CC(Cl)=C3)N=C(N[C@H]4[C@@H](N)CCCC4)N=C12.[H]Cl
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Chemical NameN2-((1S,2R)-2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dai Y, et al. Cell Cycle. 2002 Mar-Apr;1(2):143-52.
2. Yu C, et al. Cancer Res. 2003 Apr 15;63(8):1822-33.
3. Dai X, et al. Cell Cycle. 2012 Aug 15;11(16):3079-86.
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