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Bcl-xL antagonist 2
CAS No. 1235032-75-3
Bcl-xL antagonist 2( —— )
Catalog No. M28193 CAS No. 1235032-75-3
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin’s lymphoma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 192 | In Stock |
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| 5MG | 169 | In Stock |
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| 10MG | 261 | In Stock |
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| 25MG | 471 | In Stock |
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| 50MG | 642 | In Stock |
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| 100MG | 826 | In Stock |
|
| 200MG | 1107 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBcl-xL antagonist 2
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NoteResearch use only, not for human use.
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Brief DescriptionBcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin’s lymphoma.
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DescriptionBcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin’s lymphoma.(In Vivo):Bcl-xL antagonist 2 (1 mg/kg;i.v.) exhibits good PK profile with CL, Vss, t1/2 and F of 0.47 mL/min/kg, 0.16L/kg, 6.0 h and 16% in rats.
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In Vitro——
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In VivoAssessment of Pharmacokinetics (PK) profile of Bcl-xL antagonist 2 (compound 14) in rat.
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Synonyms——
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PathwayAngiogenesis
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TargetBcl-2
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1235032-75-3
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Formula Weight436.51
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Molecular FormulaC21H16N4O3S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (143.18 mM)
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SMILESO=C(O)C=1N=C(SC1)N2CC=3C(=CC=CC3CC2)C(=O)NC4=NC=5C=CC=CC5S4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7.
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