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A09-003
CAS No. 2911646-14-3
A09-003( —— )
Catalog No. M37235 CAS No. 2911646-14-3
A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 445 | Get Quote |
|
| 5MG | 686 | Get Quote |
|
| 10MG | 938 | Get Quote |
|
| 25MG | 1398 | Get Quote |
|
| 50MG | 1822 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameA09-003
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NoteResearch use only, not for human use.
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Brief DescriptionA09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.
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DescriptionA09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBCL | Apoptosis | CDK
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Research Area——
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Indication——
Chemical Information
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CAS Number2911646-14-3
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Formula Weight374.48
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Molecular FormulaC23H26N4O
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Purity>98% (HPLC)
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Solubility——
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SMILESN=1C=CC(=CC1NC2=CC=CC(=C2)N3CCNCCC3)C=4C=CC=CC4OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sim KM, et al. A new cyclin-dependent kinase-9 inhibitor A09-003 induces apoptosis in acute myeloid leukemia cells with reduction of myeloid cell leukemia sequence-1 protein. Chem Biol Interact. 2023 Sep 1;382:110554.?
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