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BTSA1

CAS No. 314761-14-3

BTSA1( —— )

Catalog No. M19903 CAS No. 314761-14-3

BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 67 In Stock
2MG 36 In Stock
5MG 61 In Stock
10MG 116 In Stock
25MG 188 In Stock
50MG 346 In Stock
100MG 517 In Stock
200MG Get Quote In Stock
500MG 1135 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    BTSA1
  • Note
    Research use only, not for human use.
  • Brief Description
    BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
  • Description
    BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.
  • In Vitro
    Cell Viability Assaysup>Cell Line:Human AML cell lines
  • In Vivo
    Animal Model:NOD-SCID IL2Rγ null (NSG) mice (6-8 weeks old) with THP-1 cells Dosage:10 mg/kg Administration:Intraperitoneal injection; every two days Result:Significantly increased survival when compared to vehicle-treated mice.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bax
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    314761-14-3
  • Formula Weight
    430.51
  • Molecular Formula
    C21H14N6OS2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 65 mg/mL
  • SMILES
    O=C1N(N=C(\C1=N/Nc1nccs1)c1ccccc1)c1nc(cs1)-c1ccccc1
  • Chemical Name
    1H-Pyrazole-45-dione 3-phenyl-1-(4-phenyl-2-thiazolyl)- 4-[2-(2-thiazolyl)hydrazone]

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Reyna DE et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10.
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