Cart
sales@molnova.com
TRPC6-PAM-C20
CAS No. 667427-75-0
TRPC6-PAM-C20( 3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one )
Catalog No. M28129 CAS No. 667427-75-0
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 466 | In Stock |
|
| 5MG | 432 | In Stock |
|
| 10MG | 638 | In Stock |
|
| 25MG | 1007 | In Stock |
|
| 50MG | 1330 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTRPC6-PAM-C20
-
NoteResearch use only, not for human use.
-
Brief DescriptionTRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
-
DescriptionTRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
-
In Vitro——
-
In Vivo——
-
Synonyms3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorGLP-1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number667427-75-0
-
Formula Weight363.413
-
Molecular FormulaC22H21NO4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 33.33 mg/mL (91.71 mM)
-
SMILESCOc1cc2CC(C)(C)N=C(c2cc1OC)c1cc2ccccc2oc1=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65(7):5449-5461.
molnova catalog
related products
-
Supercinnamaldehyde
Supercinnamaldehyde is a transient receptor potential anchor protein 1 (TRPA1) activator with thousands of anticancer and antimicrobial activities.
-
Vanilloid receptor a...
Vanilloid receptor antagonist 1 is a potent vanilloid receptor TRPV1 antagonist.
-
Vocacapsaicin hydroc...
Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.
