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Pinokalant

CAS No. 149759-26-2

Pinokalant( —— )

Catalog No. M36347 CAS No. 149759-26-2

Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischemic penumbra region.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Pinokalant
  • Note
    Research use only, not for human use.
  • Brief Description
    Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischemic penumbra region.
  • Description
    Pinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity.
  • In Vitro
    ——
  • In Vivo
    Pinokalant significantly reduces cortical infarct volume from 33.8 mm3 to 24.5 mm3.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel | SARS-CoV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    149759-26-2
  • Formula Weight
    712.83
  • Molecular Formula
    C41H48N2O9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(C(N(CCC1=C(OC)C(OC)=C(OC)C=C1)CCC2=C(OC)C(OC)=C(OC)C=C2)=O)(C=3C=4C(=CC(OC)=C(OC)C4)CCN3)C5=CC=CC=C5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Christensen T, et al. The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):316-24. ?
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