Cart
sales@molnova.com
A 425619
CAS No. 581809-67-8
A 425619( 1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA )
Catalog No. M22193 CAS No. 581809-67-8
A 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 178 | In Stock |
|
| 5MG | 169 | In Stock |
|
| 10MG | 258 | In Stock |
|
| 25MG | 426 | In Stock |
|
| 50MG | 586 | In Stock |
|
| 100MG | 792 | In Stock |
|
| 200MG | 1051 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameA 425619
-
NoteResearch use only, not for human use.
-
Brief DescriptionA 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
-
DescriptionA 425619 is a potent TRPV1 antagonistsystemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
-
In Vitro——
-
In Vivo——
-
Synonyms1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorTRPV1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number581809-67-8
-
Formula Weight345.33
-
Molecular FormulaC18H14F3N3O
-
Purity>98% (HPLC)
-
SolubilityDMSO:34.5 mg/mL (100 mM; Need ultrasonic)
-
SMILESFC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Chakrabarti S , Pattison L A , Singhal K , et al. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner[J]. Neuropharmacology, 2018, 143.
molnova catalog
related products
-
Palvanil
Palvanil is a fast desensitizing agonist of TRPV1. it may be promising agents in the therapy of IBS since it modulates intestinal motility and reduces visceral pain.
-
RN9893
RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.
-
TC-I2000
TC-I2000 is an TRPM8 channel blocker. Inhibits?icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50?of 53 nM.
