Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - Hydroxy-?α-?sanshool

Hydroxy-?α-?sanshool

CAS No. 83883-10-7

Hydroxy-?α-?sanshool( —— )

Catalog No. M21545 CAS No. 83883-10-7

Hydroxy- α- sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 219 In Stock
10MG 357 In Stock
25MG 587 In Stock
50MG 822 In Stock
100MG 1107 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Hydroxy-?α-?sanshool
  • Note
    Research use only, not for human use.
  • Brief Description
    Hydroxy- α- sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
  • Description
    Hydroxy- α- sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
  • In Vitro
    Hydroxy-α-sanshool (0-10 mM; 20 s) induces inward currents in cultured DRG neuron.Hydroxy-α-sanshool (1 mM; 0-1 min) increases intracellular Ca2+ in cultured DRG neuron. Cell Viability Assay Cell Line:Dorsal root ganglion (DRG) neurons Concentration:0-10 mM Incubation Time:20 s Result:Induced small but robust inward currents for DRG neuron with an EC50 of 66.2 μM.Cell Viability Assay Cell Line:Dorsal root ganglion (DRG) neurons Concentration:1 mM Incubation Time:0-1 min Result:Led to an intracellular Ca2+ increase in the majority of DRG neurons tested (98 of 100).
  • In Vivo
    Hydroxy-α-sanshool (intradermal injection; 4 mg per mouse; once) shows paw-licking response in wild-type and TRPV1-deficient mice.Hydroxy-α-sanshool (1 mM) ismarkedly aversive to WT mice, but in TRPV1 KO mice, the aversion is almost entirely eliminated (P<0.001). Animal Model:Wild-type and TRPV1-deficient mice Dosage:4 mg per mouse Administration:Intradermal injection; 4 mg per mouse; once Result:Reduced paw-licking response in TRPV1-deficient mice (160 times, P < 0.05).Showed paw-licking response in wild-type mice (mean 284.8 times) in 20 min.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPA1| TRPV1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    83883-10-7
  • Formula Weight
    263.37
  • Molecular Formula
    C16H25NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (379.68 mM)
  • SMILES
    CC(C)(CNC(/C=C/CC/C=C\C=C\C=C\C)=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Koo JY et al. Compounds from Sichuan and Melegueta peppers activate covalently and non-covalently TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • EIPA

    EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143, 10.5, 1.1, and 0.14 μM, respectively.

  • Pyr10

    Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .

  • JNJ-38893777 sulfate

    JNJ-38893777 is a potent and selective transient receptor potential vanilloid 1 (TRPV1) channel antagonist for treatment of ociceptive and neuropathic pain.

Sign In Join Free