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HC067047 Hydrochloride(883031-03-6 free base)
HC067047 Hydrochloride(883031-03-6 free base)
CAS No. 1481646-76-7
HC067047 Hydrochloride(883031-03-6 free base)( —— )
Catalog No. M23636 CAS No. 1481646-76-7
HC-067047 hydrochloride is a potent and selective TRPV4 antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 218 | In Stock |
|
| 5MG | 172 | In Stock |
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| 10MG | 258 | In Stock |
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| 25MG | 426 | In Stock |
|
| 50MG | 586 | In Stock |
|
| 100MG | 792 | In Stock |
|
| 200MG | 1051 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHC067047 Hydrochloride(883031-03-6 free base)
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NoteResearch use only, not for human use.
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Brief DescriptionHC-067047 hydrochloride is a potent and selective TRPV4 antagonist.
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DescriptionHC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 486 nM, 133nM, and 17 nM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRPV4
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Research Area——
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Indication——
Chemical Information
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CAS Number1481646-76-7
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Formula Weight507.98
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Molecular FormulaC26H29ClF3N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=C(C)N(CCCN2CCOCC2)C(C3=CC=CC=C3)=C1)NC4=CC=CC(C(F)(F)F)=C4.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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RN9893
RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.
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n-Butylidenephthalid...
(Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(5) 2.35 mM) in a noncompetitive fashion with a K(i) of 4.86 mM.
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EIPA
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143, 10.5, 1.1, and 0.14 μM, respectively.
