XY028-140
CAS No. 2229974-83-6
XY028-140( —— )
Catalog No. M28083 CAS No. 2229974-83-6
XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 76 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 250 | In Stock |
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| 50MG | 392 | In Stock |
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| 100MG | 584 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameXY028-140
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NoteResearch use only, not for human use.
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Brief DescriptionXY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.
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DescriptionXY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.(In Vitro):In A375 melanoma and T47D breast cancer cells, XY028-140(0.3 or 1 μΜ for 24h) inhibited both CDK4/6 expression and CDK4/6 activity. In T47D breast cancer cells, XY028-140(0.03, 0.1, 0.3, 1, or 3 μΜ for 11d) inhibited cancer cell proliferation in breast cancer cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorEndogenous Metabolite|Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2229974-83-6
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Formula Weight760.8
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Molecular FormulaC39H40N10O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5.56 mg/mL (7.31 mM)
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SMILESN/A
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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M2I-1
The first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2.
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Trilaciclib hydrochl...
Trilaciclib hydrochloride is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).Incubation with Trilaciclib hydrochloride (G1T28) for 24 hours can induce a strong G1 cell cycle arrest (time=0). Cells have re-entered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells By 16 hours after Trilaciclib hydrochloride washout.
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JNJ-7706621
A dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively; also exhibits activity towards CDK3, CDK4, and CDK6 (IC50s=50-250 nM).
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