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XY028-140
CAS No. 2229974-83-6
XY028-140( —— )
Catalog No. M28083 CAS No. 2229974-83-6
XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 72 | Get Quote |
|
| 10MG | 115 | Get Quote |
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| 25MG | 237 | Get Quote |
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| 50MG | 380 | Get Quote |
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| 100MG | 565 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameXY028-140
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NoteResearch use only, not for human use.
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Brief DescriptionXY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.
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DescriptionXY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereblon and CDK.(In Vitro):In A375 melanoma and T47D breast cancer cells, XY028-140(0.3 or 1 μΜ for 24h) inhibited both CDK4/6 expression and CDK4/6 activity. In T47D breast cancer cells, XY028-140(0.03, 0.1, 0.3, 1, or 3 μΜ for 11d) inhibited cancer cell proliferation in breast cancer cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorEndogenous Metabolite|Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2229974-83-6
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Formula Weight760.8
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Molecular FormulaC39H40N10O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5.56 mg/mL (7.31 mM)
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SMILESN/A
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Leung HW, et al. The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells. Cancer Chemother Pharmacol. 2018 Aug;82(2):185-197.
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