NU-6300( NU 6300 | NU6300 )

Catalog No. M13220 CAS No. 2070015-09-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NU-6300
Note

Research use only, not for human use.
Brief Description

NU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM.
Description

NU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM; shows modest effect (GI50=8 uM) against human MCF-7 breast carcinoma cells; inhibits Rb phosphorylation in Rb-positive SKUT-1B cells.
In Vitro

NU6300 (50 μM; 0-1 hour) covalently modifies and irreversible inhibits CDK2.Western Blot Analysis Cell Line:SKUT-1B cells Concentration:50 μM Incubation Time:0-1 hour Result:Affected retinoblastoma tumor suppressor protein (Rb) phosphorylation in SKUT-1B cells and covalently binded with CDK2.
In Vivo

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Synonyms

NU 6300 | NU6300
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Cancer
Indication

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CAS Number

2070015-09-5
Formula Weight

413.4933
Molecular Formula

C20H23N5O3S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 32 mg/mL
SMILES

O=S(C1=CC=C(NC2=NC(OCC3CCCCC3)=C4N=CNC4=N2)C=C1)(C=C)=O
Chemical Name

6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine

1. Anscombe E, et al. Chem Biol. 2015 Sep 17;22(9):1159-64.

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