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NU-6300
CAS No. 2070015-09-5
NU-6300( NU 6300 | NU6300 )
Catalog No. M13220 CAS No. 2070015-09-5
NU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 949 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNU-6300
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NoteResearch use only, not for human use.
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Brief DescriptionNU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM.
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DescriptionNU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM; shows modest effect (GI50=8 uM) against human MCF-7 breast carcinoma cells; inhibits Rb phosphorylation in Rb-positive SKUT-1B cells.
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In VitroNU6300 (50 μM; 0-1 hour) covalently modifies and irreversible inhibits CDK2.Western Blot Analysis Cell Line:SKUT-1B cells Concentration:50 μM Incubation Time:0-1 hour Result:Affected retinoblastoma tumor suppressor protein (Rb) phosphorylation in SKUT-1B cells and covalently binded with CDK2.
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In Vivo——
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SynonymsNU 6300 | NU6300
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2070015-09-5
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Formula Weight413.4933
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Molecular FormulaC20H23N5O3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESO=S(C1=CC=C(NC2=NC(OCC3CCCCC3)=C4N=CNC4=N2)C=C1)(C=C)=O
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Chemical Name6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Anscombe E, et al. Chem Biol. 2015 Sep 17;22(9):1159-64.
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