Cart
sales@molnova.com
NU-6300
CAS No. 2070015-09-5
NU-6300( NU 6300 | NU6300 )
Catalog No. M13220 CAS No. 2070015-09-5
NU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 949 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNU-6300
-
NoteResearch use only, not for human use.
-
Brief DescriptionNU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM.
-
DescriptionNU-6300 is the first covalent, irreversible, ATP-Competitive CDK2 inhibitor with Ki of 6 nM; shows modest effect (GI50=8 uM) against human MCF-7 breast carcinoma cells; inhibits Rb phosphorylation in Rb-positive SKUT-1B cells.
-
In VitroNU6300 (50 μM; 0-1 hour) covalently modifies and irreversible inhibits CDK2.Western Blot Analysis Cell Line:SKUT-1B cells Concentration:50 μM Incubation Time:0-1 hour Result:Affected retinoblastoma tumor suppressor protein (Rb) phosphorylation in SKUT-1B cells and covalently binded with CDK2.
-
In Vivo——
-
SynonymsNU 6300 | NU6300
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number2070015-09-5
-
Formula Weight413.4933
-
Molecular FormulaC20H23N5O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 32 mg/mL
-
SMILESO=S(C1=CC=C(NC2=NC(OCC3CCCCC3)=C4N=CNC4=N2)C=C1)(C=C)=O
-
Chemical Name6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Anscombe E, et al. Chem Biol. 2015 Sep 17;22(9):1159-64.
molnova catalog
related products
-
MBQ-167
MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).
-
CDK9-IN-1
CDK9-IN-1 is a potent, selective CDK9 inhibitor with IC50 of 39 nM (CDK9/CycT1), >10-fold selectivity over CDK4 and >100-fold over CDK1/2/3/5/6/7, inhibits HIV-1 replication in cellular assays.
-
Cucurbitacin E
Cucurbitacin E is a natural compound which from the climbing stem of Cucumic melo L. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.
