MTOB( 4-methylthio 2-oxobutyric acid | KMBA | MTOB salt | α-keto-γ-Methylthiobutyric acid )

Catalog No. M28000 CAS No. 51828-97-8

MTOB is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.

Purity : >98% (HPLC)

COA

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Biological Information

Product Name

MTOB
Note

Research use only, not for human use.
Brief Description

MTOB is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.
Description

MTOB is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.
In Vitro

MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7.
In Vivo

MTOB sodium (860 mg/kg; IP, at 1 h and 18 h after the first injury) effectively suppresses the increases duration of righting reflex, and significantly decreased neurological severity score (NSS) scores. Animal Model:C57BL/6 mice (traumatic brain injury)Dosage:860 mg/kg Administration:IP, at 1 h and 18 h after the first injuryResult:Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores.
Synonyms

4-methylthio 2-oxobutyric acid | KMBA | MTOB salt | α-keto-γ-Methylthiobutyric acid
Pathway

Others
Target

Other Targets
Recptor

Antiviral
Research Area

——
Indication

——

Chemical Information

CAS Number

51828-97-8
Formula Weight

170.16
Molecular Formula

C5H7NaO3S
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 125 mg/mL (734.60 mM)
SMILES

[Na+].CSCCC(=O)C([O-])=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Byoung-Kwon Chun, et al. Preparation of nucleosides and methods for treatment of viral infections. WO2022047065A2

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