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Home - Products - Cell Cycle/DNA Damage - AChR - VU0453595

VU0453595

CAS No. 1432436-13-9

VU0453595( VU-0453595 | VU 0453595 )

Catalog No. M27939 CAS No. 1432436-13-9

VU0453595 is a M1 positive allosteric modulator (PAM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 57 Get Quote
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10MG 147 Get Quote
25MG 286 Get Quote
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Biological Information

  • Product Name
    VU0453595
  • Note
    Research use only, not for human use.
  • Brief Description
    VU0453595 is a M1 positive allosteric modulator (PAM).
  • Description
    VU0453595 is a M1 positive allosteric modulator (PAM).
  • In Vitro
    Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs).
  • In Vivo
    VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD).VU0453595 (1-10?mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration. Animal Model:Male C57BL6/J mice (8-9 weeks old)Dosage:1, 3, or 10?mg/kg Administration:Intraperitoneal (i.p.); 10?mL/kg; administered 30?min before the social interaction test Result:Rescued deficits in social interaction observed in PCP-treated mice.
  • Synonyms
    VU-0453595 | VU 0453595
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    AChR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1432436-13-9
  • Formula Weight
    322.343
  • Molecular Formula
    C18H15FN4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (310.23 mM)
  • SMILES
    Cn1cc(cn1)-c1ccc(CN2Cc3ncccc3C2=O)c(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Scott DE, et al. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. ChemMedChem. 2015 Feb;10(2):296-303.
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