Cart
sales@molnova.com
VU0453595
CAS No. 1432436-13-9
VU0453595( VU-0453595 | VU 0453595 )
Catalog No. M27939 CAS No. 1432436-13-9
VU0453595 is a M1 positive allosteric modulator (PAM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
|
| 2MG | 36 | In Stock |
|
| 5MG | 55 | In Stock |
|
| 10MG | 93 | In Stock |
|
| 25MG | 181 | In Stock |
|
| 50MG | 275 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVU0453595
-
NoteResearch use only, not for human use.
-
Brief DescriptionVU0453595 is a M1 positive allosteric modulator (PAM).
-
DescriptionVU0453595 is a M1 positive allosteric modulator (PAM).
-
In VitroApplication of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs).
-
In VivoVU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD).VU0453595 (1-10?mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration. Animal Model:Male C57BL6/J mice (8-9 weeks old)Dosage:1, 3, or 10?mg/kg Administration:Intraperitoneal (i.p.); 10?mL/kg; administered 30?min before the social interaction test Result:Rescued deficits in social interaction observed in PCP-treated mice.
-
SynonymsVU-0453595 | VU 0453595
-
PathwayCell Cycle/DNA Damage
-
TargetAChR
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1432436-13-9
-
Formula Weight322.343
-
Molecular FormulaC18H15FN4O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (310.23 mM)
-
SMILESCn1cc(cn1)-c1ccc(CN2Cc3ncccc3C2=O)c(F)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Scott DE, et al. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. ChemMedChem. 2015 Feb;10(2):296-303.
molnova catalog
related products
-
PHA 543613
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
-
Mitotan
Mitotane(2,4′-DDD), an isomer of DDD and derivative of DDT, is an antineoplastic medication used in the treatment of adrenocortical carcinoma.
-
Thiacloprid
Thiacloprid, a chloronicotinyl insecticide, acts as a selective agonist at insect nAChRs. The IC50 values are 2.7 and 860 nM for Drosophilan AChRs and M10 mouse fibroblast cells expressing α4β2 subunit-containing nAChRs, respectively.
