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EF24

CAS No. 342808-40-6

EF24( EF-24 | 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone )

Catalog No. M27874 CAS No. 342808-40-6

EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	81	In Stock
5MG	73	In Stock
10MG	128	In Stock
25MG	235	In Stock
50MG	346	In Stock
100MG	523	In Stock
200MG	Get Quote	In Stock
500MG	1107	In Stock
1G	1479	In Stock

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Biological Information

Product Name

EF24
Note

Research use only, not for human use.
Brief Description

EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK.
Description

EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral squamous cell carcinoma (OSCC) via deactivation of the MAPK/ERK signaling pathway.
In Vitro

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In Vivo

——
Synonyms

EF-24 | 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
Pathway

Apoptosis
Target

PERK
Recptor

——
Research Area

——
Indication

——

Chemical Information

CAS Number

342808-40-6
Formula Weight

347.79
Molecular Formula

C19H16ClF2NO
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (160.60 mM)
SMILES

Cl.Fc1ccccc1\C=C1/CNC\C(=C/c2ccccc2F)C1=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhang M, et al. A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance. Nat Chem Biol. 2011 Sep 4;7(10):671-7.

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