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BTdCPU
CAS No. 1257423-87-2
BTdCPU( —— )
Catalog No. M20636 CAS No. 1257423-87-2
BTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 250 | In Stock |
|
| 5MG | 302 | In Stock |
|
| 10MG | 466 | In Stock |
|
| 25MG | 753 | In Stock |
|
| 50MG | 1051 | In Stock |
|
| 100MG | 1414 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2762 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBTdCPU
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NoteResearch use only, not for human use.
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Brief DescriptionBTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
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DescriptionBTdCPU is a potent heme-regulated eIF2α kinase (HRI) activator. BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
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In VitroWestern Blot Analysis Cell Line:MM1.S and MM1.R cells Concentration:10 μMIncubation Time:0, 4, 8 h Result:Induced phosphorylation of eIF2α and upregulated mRNA and protein levels of the pro-apoptotic protein CHOP.Western Blot Analysis Cell Line:Bone marrow mononuclear cells (MNC) from multiple myeloma (MM) patient or healthy donor Concentration:10 μM Incubation Time:0, 4, 8 h Result:Induced early expression of CHOP in MM patient cells, but not in healthy bone marrow mononuclear cells (MNC).
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In VivoAnimal Model:Female nude mice (mice xenograft breast tumors model).Dosage:175 mg/kg Administration:Intraperitoneal injection; single daily for 21 days Result:Led to complete tumor stasis,which persisted for the remainder of the 3-week study.Showed good safety in mice.
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Synonyms——
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PathwayApoptosis
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TargetPERK
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RecptoreIF-2α
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Research Area——
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Indication——
Chemical Information
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CAS Number1257423-87-2
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Formula Weight339.2
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Molecular FormulaC13H8Cl2N4OS
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL?(737.03 mM)
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SMILESClc1ccc(NC(=O)Nc2ccc3nnsc3c2)cc1Cl
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Chemical Name1-(Benzo[d][123]thiadiazol-6-yl)-3-(34-dichlorophenyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Burwick N Zhang MYet al.The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma[J].Leuk Res. 2017 Apr;55:23-32.?
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