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Home - Products - Metabolic Enzyme/Protease - DPP - Diprotin A

Diprotin A

CAS No. 90614-48-5

Diprotin A( Ile-Pro-Ile )

Catalog No. M27813 CAS No. 90614-48-5

Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Diprotin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
  • Description
    Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
  • In Vitro
    Western Blot Analysis Cell Line:Human endothelial cells Concentration:100?μM Incubation Time:30?minutes after CXCR4-blocker or Src-inhibitor treatment Result:Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs.
  • In Vivo
    Animal Model:Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice Dosage:70?μg/kg Administration:Intraperitoneal injection; twice daily; 7 days Result:Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
  • Synonyms
    Ile-Pro-Ile
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    DPP
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    90614-48-5
  • Formula Weight
    341.452
  • Molecular Formula
    C17H31N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : ≥ 100 mg/mL (292.87 mM))
  • SMILES
    CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.
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