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Gemigliptin

CAS No. 911637-19-9

Gemigliptin( LC15-0444 | LC150444 | LC 150444 )

Catalog No. M16542 CAS No. 911637-19-9

A novel potent, selective, competitive and orally active DPP4 inhibitor with potential for the treatment of type 2 diabetes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 50 In Stock
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25MG 143 In Stock
50MG 245 In Stock
100MG 385 In Stock
500MG 872 In Stock
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Biological Information

  • Product Name
    Gemigliptin
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent, selective, competitive and orally active DPP4 inhibitor with potential for the treatment of type 2 diabetes.
  • Description
    A novel potent, selective, competitive and orally active DPP4 inhibitor with potential for the treatment of type 2 diabetes; exhibits potent anti-glycation properties in vitro and in vivo, also improves renal function and attenuates podocyte injury in mice with diabetic nephropathy.Diabetes Approved.
  • In Vitro
    Gemigliptin dose-dependently inhibits the formation of AGE-BSA with IC50 of 11.69 mM.Gemigliptin dose-dependently suppressed the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM.Gemigliptin is a competitive inhibitor with a Ki of 7.25 nM.
  • In Vivo
    Gemigliptin (100 mg/kg; i.g.; daily; for 12 weeks) inhibits AGEs formation and AGE cross-links in vivo.Gemigliptin dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys. Animal Model:Male C57BL/KsJ-db/db mice (7 weeks old) Dosage:100 mg/kg Administration:Oral gavage, daily, for 12 weeks Result:Significantly reduced circulating AGE levels by 44.5% in serum.
  • Synonyms
    LC15-0444 | LC150444 | LC 150444
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    DPP
  • Recptor
    DPP
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    911637-19-9
  • Formula Weight
    489.37
  • Molecular Formula
    C18H19F8N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 122.5 mg/mL 250.33 mM
  • SMILES
    C1CC(CN(C1=O)CC(CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F)N)(F)F
  • Chemical Name
    (S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lim KS, et al. Br J Clin Pharmacol. 2009 Dec;68(6):883-90. 2. Hwang HJ, et al. Mol Cell Endocrinol. 2014 Jul 5;392(1-2):1-7. 3. Jung E, et al. Eur J Pharmacol. 2014 Dec 5;744:98-102. 4. Jung E, et al. Eur J Pharmacol. 2015 Aug 15;761:116-24.
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