1,4-DPCA

Research use only, not for human use.

1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 μM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).

1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 μM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).(In Vitro):1,4-DPCA significantly reduces the colony sizes and invasive branches of T4-2 (10 μM) and ZR-75-1 cells (20 μM). 1,4-DPCA inhibits the proliferation in T4-2, ZR-75-1, MDA-MB-231 cells, and MDA-MB-157. In mouse B6 cells, 1,4-DPCA specifically increases the expression of proangiogenic target genes including Hmox1 and Vegfa, and proglycolytic targets including Ldh-a, Pdk1, Glut1, and Pgk1.(In Vivo):In mice, 1,4-DPCA effectively inhibits collagen deposition within and on the outer surface of the disc, and limits connective tissue ingrowth. 1,4-DPCA suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) discs implanted in the peritoneal cavity.

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Angiogenesis

HIF/HIF Prolyl-hydroxylase

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331830-20-7

240.21

C13H8N2O3

>98% (HPLC)

In Vitro:?DMSO : 12.5 mg/mL (52.04 mM)

O=C(O)C1=CN=C2C=3N=CC=CC3C=CC2C1=O

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(-20℃)

With Ice Pack

≥ 2 years