2-Methoxyestradiol

Research use only, not for human use.

2-Methoxyestradiol (2ME2;NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent.

2-Methoxyestradiol (2ME2;NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro; suppresses microtubule dynamic instability in living interphase cells with mitotic IC50 of 1.2 uM, inhibits bFGF and VEGF-induced neovascularization and suppresses the growth of human breast carcinoma in mice; also downregulates hypoxia-inducible factor-1 (HIF) at the posttranscriptional level and inhibits HIF-1-induced transcriptional activation of VEGF expression.

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2ME2 | NSC-659853

Angiogenesis

HIF/HIF Prolyl-hydroxylase

HIF-1α|HIF-2α|Microtubuledepolymerization

Cancer

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362-07-2

302.4079

C19H26O3

>98% (HPLC)

DMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL

OC1=C(OC)C=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])CCC2=C1

Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17.beta.)-

(-20℃)

With Ice Pack

≥ 2 years