Cart
sales@molnova.com
Verapamil
CAS No. 52-53-9
Verapamil( NSC 135784 | CP-16533-1 | (±)-Verapamil )
Catalog No. M27305 CAS No. 52-53-9
Verapamil is a calcium channel blocker and an orally active and effective inhibitor of P-gp.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 10MG | 29 | In Stock |
|
| 25MG | 45 | In Stock |
|
| 50MG | 62 | In Stock |
|
| 100MG | 90 | In Stock |
|
| 200MG | 136 | In Stock |
|
| 500MG | 226 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVerapamil
-
NoteResearch use only, not for human use.
-
Brief DescriptionVerapamil is a calcium channel blocker and an orally active and effective inhibitor of P-gp.
-
DescriptionVerapamil is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias, and angina research.(In Vitro):Verapamil inhibits the EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells with an IC50 of 98.0 μM in a concentration-dependent manner.(In Vivo):Verapamil (1 mg/kg;i.v.) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia. Verapamil(oral) is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation.
-
In Vitro——
-
In Vivo——
-
SynonymsNSC 135784 | CP-16533-1 | (±)-Verapamil
-
PathwayMetabolic Enzyme/Protease
-
TargetP450
-
RecptorPotassium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number52-53-9
-
Formula Weight454.611
-
Molecular FormulaC27H38N2O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (219.97 mM)
-
SMILESCOc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Andrew P Wojtovich, et al. The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels. Basic Res Cardiol. 2009 Mar;104(2):121-9.
molnova catalog
related products
-
NSC 207895
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
-
Furafylline
Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)
-
Rhodionin
Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs; they can significantly suppress the elevation of the postprandial blood triglyceride level suggests that they may be to the treatment of lifestyle-related diseases such as hyperlipidemia and exogeneous obesity and to health foods.
