Mc-MMAE

Research use only, not for human use.

Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.

Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.(In Vitro):The synthesis of Mc-MMAE requires the addition of maleimidohexanoic acid in a solution of monomethyl auristatin E in dichloromethane, followed by addition of diethyl cyanophosphonate and diisopropylethylamine .

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Maleimidocaproyl-monomethylauristatin E

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

IKKα

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863971-24-8

911.195

C49H78N6O10

>98% (HPLC)

In Vitro:?DMSO : 180 mg/mL (197.55 mM)

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)C(C)C

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(-20℃)

With Ice Pack

≥ 2 years