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Mc-MMAE
CAS No. 863971-24-8
Mc-MMAE( Maleimidocaproyl-monomethylauristatin E )
Catalog No. M26983 CAS No. 863971-24-8
Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 69 | In Stock |
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| 5MG | 123 | In Stock |
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| 10MG | 198 | In Stock |
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| 25MG | 345 | In Stock |
|
| 50MG | 550 | In Stock |
|
| 100MG | 918 | In Stock |
|
| 200MG | 1237 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMc-MMAE
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NoteResearch use only, not for human use.
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Brief DescriptionMc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.
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DescriptionMc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.(In Vitro):The synthesis of Mc-MMAE requires the addition of maleimidohexanoic acid in a solution of monomethyl auristatin E in dichloromethane, followed by addition of diethyl cyanophosphonate and diisopropylethylamine .
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In Vitro——
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In Vivo——
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SynonymsMaleimidocaproyl-monomethylauristatin E
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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RecptorIKKα
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Research Area——
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Indication——
Chemical Information
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CAS Number863971-24-8
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Formula Weight911.195
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Molecular FormulaC49H78N6O10
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 180 mg/mL (197.55 mM)
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SMILESCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)C(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pletz N, et al. Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor. Exp Dermatol. 2012 Apr;21(4):301-4.
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