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Ch55
CAS No. 110368-33-7
Ch55( CH 55 | Ch-55 | 3,5-Di-tert-butylchalcone )
Catalog No. M26646 CAS No. 110368-33-7
Ch55 is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 82 | In Stock |
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| 5MG | 75 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 254 | In Stock |
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| 50MG | 386 | In Stock |
|
| 100MG | 600 | In Stock |
|
| 200MG | 825 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCh55
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NoteResearch use only, not for human use.
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Brief DescriptionCh55 is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors.
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DescriptionCh55 is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.(In Vitro):In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein.
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In Vitro——
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In Vivo——
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SynonymsCH 55 | Ch-55 | 3,5-Di-tert-butylchalcone
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PathwayMetabolic Enzyme/Protease
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TargetRetinoid Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number110368-33-7
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Formula Weight364.48
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Molecular FormulaC24H28O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (137.18 mM)
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SMILESCC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)\C=C\c1ccc(cc1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.
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