Ch55

Research use only, not for human use.

Ch55 is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors.

Ch55 is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.(In Vitro):In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein.

——

——

CH 55 | Ch-55 | 3,5-Di-tert-butylchalcone

Metabolic Enzyme/Protease

Retinoid Receptor

——

——

——

110368-33-7

364.48

C24H28O3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (137.18 mM)

CC(C)(C)c1cc(cc(c1)C(C)(C)C)C(=O)\C=C\c1ccc(cc1)C(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years