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Tretinoin
CAS No. 302-79-4
Tretinoin( atRA | NSC 122578 | NSC 122758 | RA | Vitamin A Acid )
Catalog No. M13949 CAS No. 302-79-4
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 50MG | 28 | In Stock |
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| 100MG | 39 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 59 | In Stock |
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| 1G | 73 | In Stock |
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Biological Information
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Product NameTretinoin
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NoteResearch use only, not for human use.
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Brief DescriptionAn important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS.
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DescriptionAn important regulator of gene expression during growth and development, and in neoplasm. Tretinoin, also known as retinoic acid and derived from maternal vitamin a, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin disease. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
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In VitroRetinoic acid (GMP) time- and dose- dependently induces differentiation of EC cells and ES cells into specific cell types.Retinoic acid (GMP) induces partial differentiation of F9 embryonal carcinoma cells into endoderm cells.Retinoic acid (GMP) (100 nM; 2-8 d) promotes photoreceptor differentiation in early postnatal retinal cultures.Retinoic acid (GMP) (0.1 μM; 10-12 d) induces human SH-SY5Y neuroblastoma cells differentiation with long cell processes. Retinoic acid (GMP) (0-10 μM; 48 h) dose-dependently induces morphologic differentiation of LA-N-1 human neuroblastoma cells.
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In VivoRetinoic acid (GMP) (0.3 μM; embryos are immersed in tank water containing retinoic acid) accelerates of rod differentiation is observed following 24 and 48 hours of applicationin zebrafish.
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SynonymsatRA | NSC 122578 | NSC 122758 | RA | Vitamin A Acid
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PathwayMetabolic Enzyme/Protease
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TargetRetinoid Receptor
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RecptorRAR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number302-79-4
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Formula Weight300.44
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Molecular FormulaC20H28O2
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Purity>98% (HPLC)
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SolubilityEthanol: 6 mg/mL (19.97 mM); DMSO: 60 mg/mL (199.73 mM)
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SMILESO=C(O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C
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Chemical Name(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Manzano VM, et al. J Pharmacol Exp Ther, 1999, 289(1), 123-132.
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