Arimoclomol( BRX-220 free base )

Catalog No. M26548 CAS No. 289893-25-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Arimoclomol
Note

Research use only, not for human use.
Brief Description

Arimoclomol is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).
Description

Arimoclomol is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).(In Vivo):In male Wistar rats, Arimoclomol (20 mg/kg; gavage) protects cholecystokinin-octapeptide (CCK)-induced acute pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased.
In Vitro

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In Vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect againstcholecystokinin-octapeptide (CCK)-induced acute pancreatitis. Animal Model:Male Wistar rats weighing 240 to 270 gDosage:20 mg/kg Administration:Administered intragastrically, for 5 daysResult:Had a protective effect against CCK-induced acute pancreatitis.
Synonyms

BRX-220 free base
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

AP-1| LOX| NF-κB| Parasite
Research Area

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Indication

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1.Hadjipavlou-Litina D, et al. Kukoamine A analogs with lipoxygenase inhibitory activity. J Enzyme Inhib Med Chem. 2009 Oct;24(5):1188-93.

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