PF-04929113 Mesylate( SNX-5422 Mesylate | PF04929113 Mesylate | SNX5422 Mesylate )

Catalog No. M10581 CAS No. 1173111-67-5

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Product Name

PF-04929113 Mesylate
Note

Research use only, not for human use.
Brief Description

The prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor.
Description

The prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor; inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo.Blood Cancer Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

SNX-5422 Mesylate | PF04929113 Mesylate | SNX5422 Mesylate
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP90|HER2
Research Area

Cancer
Indication

Blood cancer

CAS Number

1173111-67-5
Formula Weight

617.6377
Molecular Formula

C26H34F3N5O7S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C.CS(=O)(=O)O
Chemical Name

Glycine, trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester, methanesulfonate (1:1)

1. Lamoureux F, et al. Clin Cancer Res. 2011 Jul 15;17(14):4916. 2. Rajan A, et al. Clin Cancer Res. 2011 Nov 1;17(21):6831-9.

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