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(R)-ADX-47273
CAS No. 851881-59-9
(R)-ADX-47273( —— )
Catalog No. M26528 CAS No. 851881-59-9
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
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| 2MG | 33 | In Stock |
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| 5MG | 56 | In Stock |
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| 10MG | 90 | In Stock |
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| 25MG | 164 | In Stock |
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| 50MG | 254 | In Stock |
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| 100MG | 383 | In Stock |
|
| 200MG | 533 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name(R)-ADX-47273
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NoteResearch use only, not for human use.
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Brief Description(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
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Description(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
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In Vitro(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM.
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorLIM Kinase (LIMK)
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Research Area——
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Indication——
Chemical Information
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CAS Number851881-59-9
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Formula Weight369.372
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Molecular FormulaC20H17F2N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (270.74 mM)
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SMILESFc1ccc(cc1)C(=O)N1CCC[C@H](C1)c1nc(no1)-c1ccc(F)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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LY2979165
LY2979165 is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
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GW791343 3HCl
GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
