(R)-ADX-47273( —— )

Catalog No. M26528 CAS No. 851881-59-9

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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5MG	102	Get Quote
10MG	177	Get Quote
25MG	322	Get Quote
50MG	528	Get Quote
100MG	755	Get Quote
500MG	1521	Get Quote
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Biological Information

Product Name

(R)-ADX-47273
Note

Research use only, not for human use.
Brief Description

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
Description

(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).
In Vitro

(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM.
In Vivo

——
Synonyms

——
Pathway

Neuroscience
Target

GluR
Recptor

LIM Kinase (LIMK)
Research Area

——
Indication

——

Chemical Information

CAS Number

851881-59-9
Formula Weight

369.372
Molecular Formula

C20H17F2N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (270.74 mM)
SMILES

Fc1ccc(cc1)C(=O)N1CCC[C@H](C1)c1nc(no1)-c1ccc(F)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Wu J, Liu S, Fan Z, Zhang L, Tian Y, Yang R. A novel and selective inhibitor of PKC ζ potently inhibits human breast cancer metastasis in vitro and in mice. Tumour Biol. 2016 Jun;37(6):8391-401.

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