VAF347

Research use only, not for human use.

VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.

VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.(In Vitro):In HL-60 cells, VAF347 augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of the partners in the signal body appear to be enhanced: Fgr interacts with c-Cbl, CD38, and pS259c-Raf, and AhR interacts with c-Cbl and Lyn. VAF347 enhances retinoic acid-induced cell cycle arrest.(In Vivo):AhR-deficient mice are resistant to VAF347's ability to block allergic lung inflammation in vivo.

Cell Cycle Analysis Cell Line:HL-60 cells Concentration:10 nM, 100 nM, 1 μM, 10 μM, 20 μM Incubation Time:48 hours or 72 hours Result:Enhanced retinoic acid-induced cell cycle arrest in G1/0.Western Blot Analysis Cell Line:HL-60 cells Concentration:20 μM Incubation Time:48 hours Result:Augmented retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox.

——

——

Endocrinology/Hormones

AhR

——

——

——

574759-62-9

349.74

C17H11ClF3N3

>98% (HPLC)

In Vitro:?DMSO : 31.25 mg/mL (89.35 mM)

FC(F)(F)c1ccc(Nc2nccc(n2)-c2cccc(Cl)c2)cc1

——

(-20℃)

With Ice Pack

≥ 2 years