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Nimodipine

CAS No. 66085-59-4

Nimodipine( Admon | BAY-e 9736 | Periplum )

Catalog No. M15515 CAS No. 66085-59-4

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 33 In Stock
100MG 29 In Stock
200MG Get Quote In Stock
500MG 60 In Stock
1G 83 In Stock
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Biological Information

  • Product Name
    Nimodipine
  • Note
    Research use only, not for human use.
  • Brief Description
    Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.
  • Description
    Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.(In Vitro):Nimodipine (1.5~150 μg/ml; 15 minutes; B16a and W256 cells) results in a dose-dependent inhibition of B16a and W256 tumor-cell-induced platelet aggregation. Nimodipine is also inhibitory in a homologous system.(In Vivo):Nimodipine (0.2 μg/μl, intrathecal administration) prevents subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration.Nimodipine(0.1~80 mg/kg; p.o.) results in a significant dose-dependent inhibition of spontaneous metastasis.
  • In Vitro
    Nimodipine (1.5~150 μg/ml; 15 minutes; B16a and W256 cells) results in a dose-dependent inhibition of B16a and W256 tumor-cell-induced platelet aggregation. Nimodipine is also inhibitory in a homologous system.
  • In Vivo
    Nimodipine (0.2 μg/μl, intrathecal administration) prevents subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration.Nimodipine(0.1~80 mg/kg; p.o.) results in a significant dose-dependent inhibition of spontaneous metastasis. Animal Model:New Zealand white rabbits Dosage:0.2 μg/μl Administration:Intrathecal administration Result:Prevented subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration.
  • Synonyms
    Admon | BAY-e 9736 | Periplum
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR| Calcium Channel| Mineralocorticoid Receptor
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    66085-59-4
  • Formula Weight
    418.44
  • Molecular Formula
    C21H26N2O7
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 84 mg/mL (200.74 mM); DMSO: 84 mg/mL (200.74 mM)
  • SMILES
    CC1=C(C(OCCOC)=O)C(C2=CC([N+]([O-])=O)=CC=C2)C(C(OC(C)C)=O)=C(C)N1
  • Chemical Name
    3-isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Weant KA, et al. PharmacOthersapy. 2010 Apr;30(4):405-17.
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