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Telomerase-IN-2

CAS No. 1610878-54-0

Telomerase-IN-2( Telomerase inhibitor 2 )

Catalog No. M26478 CAS No. 1610878-54-0

Telomerase-IN-2 shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Telomerase-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    Telomerase-IN-2 shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 μM).
  • Description
    Telomerase-IN-2 shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 μM).(In Vitro):Telomerase-IN-2 exhibits high activity against Hela, SMMC-7721, SGC-7901, U87 and HepG2 cell lines in the anticancer activity assay in vitro.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Telomerase inhibitor 2
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Telomerase
  • Recptor
    IRE1/XBP1s
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1610878-54-0
  • Formula Weight
    633.698
  • Molecular Formula
    C34H39N3O9
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (394.51 mM)
  • SMILES
    COc1cc(OC)c2c(c1)oc(-c1cc(OC)c(OC)c(OC)c1)c(OCCCCN1CCN(CC1)C(=O)c1ccncc1)c2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Grandjean JMD, et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming. Nat Chem Biol. 2020;16(10):1052-1061.
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