360A

Research use only, not for human use.

360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).

360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).

360A inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.

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Cell Cycle/DNA Damage

Telomerase

Telomerase

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794458-56-3

449.5

C27H23N5O2

>98% (HPLC)

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C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12

33'-((pyridine-26-dicarbonyl)bis(azanediyl))bis(1-methylquinolin-1-ium) iodide; (26-NN′-Methyl-quinolinio-3-yl)-pyridine dicarboxamide

(-20℃)

With Ice Pack

≥ 2 years