WAY-181187

Research use only, not for human use.

WAY-181187 has high-affinity binding at the human 5-HT6 receptor.

WAY-181187 is a potent and selective 5-HT6 receptor agonist. WAY-181187 possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (WAY-181187: EC50=6.6 nM, Emax=93%). In the rat frontal cortex, acute administration of WAY-181187 (3-30 mg/kg, subcutaneous (s.c.)) significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.

Western Blot Analysis Cell Line:HEK/HA-5-HT6 receptor cells Concentration:1 and 10 μM Incubation Time:Pretreatment 5 minutes Result:Increased activation of ERK1/2 both at 1 and 10 μM concentrations.

Animal Model:Adult male Sprague-Dawley rats weighing 280–350 g Dosage:3, 10, or 30 mg/kg Administration:Acute dministered by s.c.Result:Significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.

WAY-181187 | WAY 181187 | WAY181187

Cell Cycle/DNA Damage

Telomerase

5-HT6

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554403-49-5

380.87

C15H13ClN4O2S2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (262.56 mM)

c1ccc2c(c1)c(cn2S(=O)(=O)c1c(nc2n1ccs2)Cl)CCN

2-(1-((6-Chloroimidazo(2,1-b)(1,3)thiazol-5-yl)sulfonyl)-1H-indol-3-yl)ethylamine

(-20℃)

With Ice Pack

≥ 2 years