DHODH-IN-8

Research use only, not for human use.

DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) .

DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.(In Vitro):Dihydroorotic acid dehydrogenase (DHODH) is an attractive chemotherapeutic target among various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and is used to treat human diseases. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by using the FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. Human DHODH (HsDHODH)a and Plasmodium falciparum DHODH (PfDHODH) are both DHODHs using respiratory quinones as terminal electron acceptors.

The dihydroorotate dehydrogenases (DHODHs) are attractive chemotherapeutic targets in various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and for the treatment of human disease. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by utilizing an FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. The human DHODH (HsDHODH)a and the P. falciparum DHODH (PfDHODH) both belong to the group of class 2 DHODHs that use respiratory quinones as the terminal electron acceptors.

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Metabolic Enzyme/Protease

Dehydrogenase

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1148126-03-7

312.75

C17H13ClN2O2

>98% (HPLC)

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C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1Cl

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(-20℃)

With Ice Pack

≥ 2 years