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DHODH-IN-8
CAS No. 1148126-03-7
DHODH-IN-8( —— )
Catalog No. M26161 CAS No. 1148126-03-7
DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 249 | In Stock |
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| 2MG | 166 | In Stock |
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| 5MG | 255 | In Stock |
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| 10MG | 374 | In Stock |
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| 25MG | 562 | In Stock |
|
| 50MG | 770 | In Stock |
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| 100MG | 1051 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDHODH-IN-8
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NoteResearch use only, not for human use.
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Brief DescriptionDHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) .
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DescriptionDHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.(In Vitro):Dihydroorotic acid dehydrogenase (DHODH) is an attractive chemotherapeutic target among various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and is used to treat human diseases. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by using the FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. Human DHODH (HsDHODH)a and Plasmodium falciparum DHODH (PfDHODH) are both DHODHs using respiratory quinones as terminal electron acceptors.
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In VitroThe dihydroorotate dehydrogenases (DHODHs) are attractive chemotherapeutic targets in various pathogens, such as Plasmodium falciparum and Helicobacter pylori, and for the treatment of human disease. DHODH catalyzes the conversion of dihydroorotate (DHO) to orotate by utilizing an FMN cofactor in the only redox reaction present in the pyrimidine biosynthesis pathway. The human DHODH (HsDHODH)a and the P. falciparum DHODH (PfDHODH) both belong to the group of class 2 DHODHs that use respiratory quinones as the terminal electron acceptors.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1148126-03-7
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Formula Weight312.75
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Molecular FormulaC17H13ClN2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.I A Butovich, et al. Oxidation of linoleyl alcohol by potato tuber lipoxygenase: kinetics and positional, stereo, and geometrical (cis, trans) specificity of the reaction. Arch Biochem Biophys. 2000 Jun 1;378(1):65-77.
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