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PGS-IN-1

CAS No. 102271-49-8

PGS-IN-1( KME-4 )

Catalog No. M26023 CAS No. 102271-49-8

PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 106 In Stock
5MG 93 In Stock
10MG 170 In Stock
25MG 369 In Stock
50MG 528 In Stock
100MG 755 In Stock
200MG 1014 In Stock
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Biological Information

  • Product Name
    PGS-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).
  • Description
    PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).(In Vitro):PGS-IN-1 is the trans isomer of the synthesized α-benzulidene-γ-butyrolactone. PGS-IN-1 exhibits potent anti-inflammatory and PGS inhibitory activity with IC50 of 0.28 μM. PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase with IC50 of 1.05 μM.
  • In Vitro
    The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM).
  • In Vivo
    ——
  • Synonyms
    KME-4
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    EGFR| IGF-1R
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    102271-49-8
  • Formula Weight
    302.414
  • Molecular Formula
    C19H26O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)(C)c1cc(\C=C2/CCOC2=O)cc(c1O)C(C)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.
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